USU Conference Systems, International Conference on Tropical Medicine and Infectious Diseases (ICTROMI) 2017

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Renal Dysfunction in Liver Cirrhosis and Its Correlation with Child Pugh Score and MELD Score
gontar alamsyah siregar, Mariati Gurning

Last modified: 2017-10-27


Abstract. Background : Renal dysfunction (RD) is a serious problem and common complication in patient with liver cirrhosis. It provides a poor prognosis. The study was undertaken to asses the renal function in liver cirrhosis and find out the correlation between renal function with gradation of liver disease assessed by Child Pugh Score (CPS)  and MELD score. .Methods : This was a cross-sectional study included patients with liver cirrhosis admitted to Adam Malik Hospital Medan in June – August 2016. We divided them into two groups as not having renal dysfunction (serum creatinine ≤ 1,5 mg/dL) and having renal dysfunction (serum creatinine > 1,5 mg/dL). For the processing of data SPSS 22.0 was used. Statistical methods used : Chi square, Fisher exact, one way ANOVA, Kruskal Wallis test and Pearson coefficient of correlation. The level of significance was p<0,05. Results : 55 patients with absence of renal dysfunction were 39 (70,9%), and presented of renal dysfunction were 16 (29,1 %). There were statistically significant inverse correlation between GFR and CPS (r = -0.308), GFR and MELD score (r = -0.278 ). There were statistically significant correlation between creatinine and MELD score (r = 0.359 ), creatinine and CPS (r = 0.382) Conclusion: Significant correlations were observed between renal dysfunction and Child Pugh and MELD score. Increase of degree of liver damage is related with increase of renal impairment.

Key word : Renal Dysfunction; Cirrhosis; Child Pugh Score; MELD score