Tuberculosis is still major public health problem in Indonesia. WHO expressed the need for the participation of various stakeholders in addition to government. TB CEPAT Program aimed to increase knowledge and awareness in combatting tuberculosis. This study aimed to compare the knowledge and awareness of community, cadres and TB patients in the program areas and non program areas, and assess the role of program in combatting tuberculosis in Medan. The study used quantitative and qualitative methods, where 300 people (community, cadres, TB patients) as respondens and three key persons as informants. The findings revealed that in the program areas  the knowledge, attitude and practice of the respondents generally were more better compare to the non program areas. There was a significant difference of the knowledge and practice for community, cadres, and TB patients (p<0.05) and there was a significant difference of the attitude for community, cadres (p<0.05), but no significant difference for TB patients (p>0.05) in program areas and non program areas. The community empowerment through TB CEPAT Program had play important role in increasing knowledge, attitude, and practice of community, cadres, and TB patients. It would help the effort of TB control and prevention in Medan City.

Key words: community empowerment, tuberculosis, TB CEPAT program