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Aspergillosis is defined as a mycosis group caused by various pathogenic fungi of the Aspergillus genus. Aspergillus has more than 900 species that cause infection in human. The most common Aspergillus species that cause infection  is Aspergillus fumigatus, about 90%. Other species, Aspergillus flavus, about 10% cause invasive disease. In this case report in female, age 17 years 8 months, with major complaints of coughing up blood and after diagnostic procedures diagnosed with right pulmonary aspergilloma. The patient was performed bilobectomy thoracotomy on the lower right lung segment.