Introduction: The incidence of Sjogren’s Syndroome was estimated 4 in 100.000 of these cases with the prevalence is 0,2% to 2,7% of population. Prodominant sex female/male ratio is approximately 10:1 with peak incidence is in the fourth and fifth decade. Findings: A 29-year-old woman had dry eyes and recurrent sensation of sand in the eyes for 2 years. Schimmer’s test was positive ≤ 5mm in 5 minute  both eyes, and the autoantibodies SSA and SSB was positive. Without history head or neck radiation and result of laboratory examination hepatitis C and HIV negative.  Discussion: Until now there are no satisfying therapy for Sjogren Syndrome, only supportive therapy specific to symptomatic can be treated. Conclusion: We reported a case of Sjogren Syndrome with dry eyes symptom, polyathralgia, and fatique. Muscarinic agonist pilocarpine 5 mg PO qid and hydroxychloroquine was given. Keywords: Dry eyes, Sjogren Syndrome.