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Estimated 3.3 million Indonesian population were infected with malaria. However, extensive genetic polymorphism of the field isolates msp-1 of P. falciparum represents a major obstacle for the development of malaria treatment. The aim of this study to investigate the genetic diversity of msp-1 genotype in field isolates of P. falciparum collected in Aceh Province. A total of 90 patients enrolled in this study who were selected from positive malaria from eleven district Hospitals in Aceh from 2013-2015. Data was collected by anamnese, complete physical examination and laboratory tests for msp-1. All protocol to diagnose malaria assigned following the WHO 2010 guideline. All samples was stored in Eijkman Biology Molecular Institute, Jakarta. Among 90 samples were 57,7% male and 42,3% female with the most cases ages between 21-30 years old. Allele typing analysis displayed the high polymorphic nature of P. falciparum from Aceh, K1, MAD20 and RO33 allele types were identified. MAD20 type was the highest allele found in this study (57.9%), found as single and mixed infection, a moderate level of mixed allele was also observed.