Font Size: 

The irrational use of vancomycin in methicillin-resistant Staphylococcus aureus (MRSA) infections results in the emergence of  vancomycin-resistant Staphylococcus aureus (VRSA) pathogen, which can pose a threat to the world healthcare. A 32 year old male with hepatic cirrhosis patient admitted with recurrent gastrointestinal bleeding with a wound in his left leg since 6 months ago, the result microbiological culture showed a VRSA with minimum inhibitory concentration (MIC) vancomycin ≥ 32 μg/mL. Patients was treated with trimethoprim/sulfamethoxazole combination according to culture sensitivity. The second microbiological culture showed same result. VRSA  is a rare and difficult condition to handle. The success of therapy for this VRSA case warn us how important to cut the S.aureus distribution chain with a high level of resistance.