ABSTRACT

BACKGROUND : Leptospirosis is a widespread and potentially fatal zoonosis that is endemic in many tropical regions and causes large epidemics after heavy rainfall and flooding.¹ Severe disease is estimated to occur in 5–15% of all human infections.⁵ Mortality from severe forms is 5-40%.⁶ The laboratory confirmation of leptospirosis is based on MAT, isolation of the organism, or demonstration of leptospiral DNA by means of PCR.⁴

METHOD : This cross sectional analytic study recruited 26 hospitalized patients leptospirosis. All patients clinically suspected of leptospirosis (n = 26), admitted to the medical wards of Moewardi Hospital Central Java. Leptospirosis diagnosis was based on clinical, laboratory and epidemiological.⁷ The onset of the disease was the date when the first symptom started, and the end of the analysis was the date when the patient died or was still alive at discharge.

RESULT : Modified faine’s score ≥ 25 tend to die with proportion 45,5 %, while modified faine’s score 20 – 24 tend to heal with proportion 60 % (OR 1,250; CI 0.259-6.029; p = 1,0). Seropositive Ig M predict mortality 7,8 times higher than seronegative Ig M (OR 7.800; CI 1.162-52.353; p = 0,038). MAT positive predict mortality 10.667 times higher than MAT negative (OR 10.667; CI 1.705-66.720; p=0,015).

CONCLUSIONS :Serology marker and MAT have significant association to mortality in human leptospirosis but no significant for clinical manifestation.

KEY WORDS : Leptospirosis, Ig M, MAT, Mortality.