Invasive pulmonary aspergillosis is an extraordinary rare in immunocompetent host.  Falciparum malaria contributes to high morbidity and mortality of malaria infection cases in the world. The impairments of both humoral and cellular immunity could be the reason of invasive pulmonary aspergillosis in falciparum malaria infection.

CASE REPORT : Forty-nine years old patient came with fever, jaundice, pain in right abdomen, after visiting a remote area in Africa about one month before admission. Blood films and rapid test were positive for Plasmodium falciparum. After malaria therapy in five days, consciousness was altered into somnolence, and intubated with respiratory deterioration.