Diabetes mellitus  (DM)  is  a  group  of  chronic metabolic  diseases with characteristic  hyperglycemia  that  occurs  due  to  abnormalities  in  insulin secretion,  insulin  action  or  both.  Improved  quality  of  life  is  one  of  the  goals  of diabetes  mellitus  management  therapies,  therefore  the  studies  that  evaluate comparison  quality  of  life  in  patient with  type  2  diabetes  based  on  therapy  are needed.

This study aims to determine the major comparison of quality of life with SF-36 questionnaire in patients with type 2 diabetes who use insulin therapy and who use oral hypoglycemic drugs in H. Adam Malik Central Hospital year 2015.

This study  is a analytic observational study with design cross sectional study  with  consecutive  sampling  methode  in  accordance  with  the  inclusion criteria.  Subjects  in  the  study  consisted  of  two  groups,  namely  40  insulin  users and  40  users  OHO.  Evaluation  of  the  quality  of  life  of  patients  taken  through interviews and questionnaires using  the Short Form-36 questionnaire consisting of 8 domains of quality of life. Statistical analysis using unpaired t test and Mann-Whitney test.

Results  of  the  evaluation  of  the  quality  of  life  based  on  patient characteristics showed significant differences in the education factor (p = 0.005) and  employment  factor  (p =  0.001).  Results  of  the  evaluation  of  quality  of  life based on  therapy showed significant differences  in domain role of physical  (p = 0.005) and domain role of emotional (p = 0.038).

Thus  the quality of  life of patients with  type 2 diabetes who use  insulin better than patients with type 2 diabetes who use OHO significantly in domain role of physical  and domain role of emotional.

Keywords : Quality of Life, SF-36, Insulin Therapy, Oral Hypoglycaemic Drugs