Cytokines are polypeptides that have a wide spectrum of inflammatory, metabolic, hematopoetic and immunologic regulatory properties. The liver represent important site of synthesis and clearance organ for several cytokines. The aim of this study was to evaluate serum IL-6 in liver cirrhosis with the type of underlying disease , child pugh group and various clinical and laboratory parameter. This cross-sectional study was conducted in Adam Malik General Hospital and other related hospital from July - December 2016. We examine 75  patients with Liver cirrhosis. There were 28(37.3 %); 8(10.6 %); and 39(52%) for HBV-positive; HCV-positive and HBV- HCV negative liver cirrhosis patients, respectively. There were  14(18.7 %); 15(20 %); and 46(61.3%) for Child pugh A, B and C , repectively. This study found no significant different between HBV positive, HCV positive, and HBV HCV negative group with IL-6. There was no significant difference between child pugh group and IL-6.

Keywords: IL-6 , liver cirrhosis