USU Conference Systems, International Conference on Tropical Medicine and Infectious Diseases (ICTROMI) 2017

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Association between CD8 T-cell subsets and CD4/CD8 ratio with hs-CRP level in HIV-infected patients on antiretroviral therapy
Sophie Isabela Magdalena, Agung Nugroho, Paul Harijanto

Last modified: 2017-10-23


Due to improved access and adherence to anti retroviral therapy (ART), it is predicted that most HIV-infected persons worldwide will live longer. Nowadays the cause of death for most HIV-infected persons has changed to serious non-AIDS events (SNAEs) which is due to low grade viremia. HIV patients with ART who had undergone CD4 cell count above 500/uL and an undetectable viral load was found an increase in hs-CRP. Some conditions CD8 cells count do not decrease with CD4 cells repairs. This research was conducted in Prof Kandou General Hospital with a total sample of 35 HIV patients who had received ART with level of CD4 > 350/uL. Patients were assessed for CD8 levels, CD4/CD8 ratio and hs-CRP. This research is analytic descriptive with cross sectional study design and analysis uses Spearman correlation. The mean CD8 during the study was 1291.8 (IQR 319-2610 cells/uL), the mean ratio of CD4: CD8 was 0.57 (IQR 0.16-1.24) and median hs-CRP is 2.18 (IQR 0.3-6.6 mg/dL). There was a significant positive correlation between CD8 and hs-CRP increase (r = 0.369, p <0.05). There was a negative correlation between CD4/CD8 ratio and hs-CRP (r = -0.370, p <0.05).

Key words: CD8, CD4/CD8 ratio, hs-CRP