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Systemic Lupus Erythematosus (SLE) is an autoimmune rheumatic disease characterized by widespread inflammation and affects any organ in the body. Many autoimmune diseases result in autoantibody production, but Anti-dsDNA antibodies are highly specific to SLE. Previous study found that Anti-dsDNA antibodies are associated with severe clinical manifestations of lupus. The aim of this study was to examine the relationship between anti-dsDNA level with clinical features and laboratory findings in SLE patients. This cross-sectional study was conducted in Hospital Haji Adam Malik Medan in August-October 2016. We examine anti-dsDNA, clinical features and kidney laboratory profile in all patient. Data were statistically analyzed. 81 SLE patients with median level of anti-dsDNA 294 (6.1-1317). There was no significant relationship between increased level of Anti-dsDNA with clinical manifestations (p>0.05). There were significant relationships between increased level of Anti-dsDNA with ureum level (p=0.016), thrombocytopenia (p=0.001), leukopenia (p=0.006), renal impairment (p=0.049) and urine protein (p=0.042). Arthritis is the most frequent clinical manifestation (96.3%) from this study followed by malar rash (77.8%). Elevated anti-dsDNA level was not related with clinical manifestations but there was significant relationship with hematology disorder and kidney laboratory profiles of SLE patients. Keywords: SLE, Anti-dsDNA