Abstract. Hepatitis B virus (HBV) is one of the most contagious pathogens, where the risk of exposure is very high among health care workers, especially medical students. This study describes the protection status, history of vaccination, and history of HBV infection in medical students. Fourty-four (44) students over 18 years old were randomly selected, interviewed for their vaccination history and then had their blood serum taken for anti-HBs and anti-HBc examinations to determine the protectivity and history of infection. There were 81.8% students without protective anti-HBs level. Recent vaccination was taken by 18.2% students before starting clinical rotation and only one-fourth formed protective antibody level. Seventeen (38.6%) students had been exposed to HBV(positive anti-HBc) and only a third showed protective anti-HBs level. None of the vaccinee underwent post-vaccination serological test. These results indicated the vulnerability of medical students to the risk of HBV transmission while performing medical care. With the high incidence of HBV transmission, educational institutions are encouraged to make provisions for vulnerable student to receive booster and adequate PVST before clinical rotation.