In order to overcome malarial resistance tendency against ACT (artemisinin based combination therapy), several galenic preparations of Garciniamangostana L rindand alphamangostin as the major xanthone in this rind have been studied and they had antimalarial activity and showed its synergistic effect with artemisininin vitro. Curcumin as active component of turmeric, is also potentially to have antimalarial activity. The aim of this study was to evaluate the antimalarial activity of curcumin and dihydroartemisinin, an active metabolite of all artemisininderivates, and also to evaluate the mechanism of action of aphamangostin, curcumin, and dihydroartemisinin as antimalaria. Interaction between them each other as antimalarial in vitro was also studied. Antimalarial activity was studied in in vitro 3D7 Plasmodium falciparum cultivation incubated with these compounds to look for the IC₅₀ and ∑FIC₅₀ of them. The mechanism of action of these compounds was observed electron microscopically. The result of this promising study showed that these compounds were active antimalaria agents which inhibited hemozoin formation and there is synergistic antimalarial activity interaction between alphamangostin and dihydroartemisinin.

 

Keyword:  alphamangostin, curcumin, dihyroartemisinin, P. falciparum, invitro