Caring for schizophrenic patients can lead to emotional distress. Gender of schizophrenic patients associated with the level stress of caregiver. It remains unclear about the differences in HADS-D between female caregivers of scizophrenic patients according to gender of patients.Aims : To determine whether HADS-D score are higher in male group compare with female group. Methods: This study is an analytical study with cross-sectional approach to see the comparation in HADS-D score between 27 female caregivers of female schizophrenic patients and 27 female caregivers of male schizophrenic patients in Prof. dr. M. Ildrem Mental Hospital Medan, using instruments HADS.Results: There are no difference between female and male group in caregivers : age, education time, employment status, marital status, family income / month, Relationship with patient, caring time, time spent/weeks, and patients age, education time, employment status, marital status, PANSS score, number of relapse. The comparation between total HADS-D score between caregivers of male schizophrenic patients and caregivers of female schizophrenic patients are not significant with 7,59 ±2,64 v 8,70±3,71 (p=0,211). Conclusions: HADS-D score are not higher in caregivers of male schizophrenic patients compare with caregivers of female schizophrenic patients.

Keywords: Caregiver, Schizophrenia, HADS