Abstract

Background: Dengue fever is one of the most important emerging vector-borne viral diseases. approximately 500.000 cases out of 100 million estimated cases that develop to severe dengue infection. Patient with severe dengue (SD) could be predicted by clinical profile, laboratory and warning sign which could be saved by early interventions.

Objective : To investigate clinical manifestations, laboratorium and warning signs in chidren with dengue infection

Methods: This study was a retrospective analytic descriptive of children with dengue diagnosis in Haji Adam Malik hospital during January 2014 – May 2016. Descriptive statistics were used to describe the distribution of the patients’ characteristics, clinical and laboratory findings. Chi-square or fisher’s exact test were used to compare warning sign of severe and no severe dengue (NSD)

Results: Through medical record, we have selected 140 cases who fulfilled research criteria.  Cases were classified as SD (n=28) and NSD (n=112). Most common clinical manifestations   for NSD were abdominal pain (39.3%), myalgia (39.3%), headache (37.1%), mucosal bleeding (36.4%), petechiae (34.3%), while shock (15.7%), mucosal bleeding (15.7%), clinical fluid accumulation (15%), shortness of breath (14.3%), vomiting (13.6%), were found in SD. SGPT > 1000 IU/L (5 cases), SGOT > 1000 IU/L (9 cases), PT (10 cases) and aPTT (16 cases) were abnormal in SD. Severe dengue was more frequently found in range of white cell count 1.000-4.000 /L  and platelet count 20.000-50.000 mm/uL

Conclusion: Clinical manifestations, warning sign and laboratory finding were different between  severe and non severe dengue.

 

Key words clinical manifestation, dengue infection, severe dengue