Schizophrenia is a complex neurodevelopmental disorder with cognitive impairment as the main part. Cognitive functions include capabilities such as attention and executive functioning, assessing, monitoring and evaluating. Neurotrophin is a family of polypeptide growth factors with similar structures, involved in the process of brain development, differentiation and survival of neurons, synaptic plasticity and connectivity. BDNF regulates aspects of developmental plasticity in the brain and is involved in cognitive function. The aim of the study to determine the correlation between Montreal Cognitive Assessment Indonesian Version (MoCA-Ina) Scoreand BDNF Serum levels in schizophrenic patients. The study was held in October 2016 - March 2017, and was the first in Indonesia, especially in North Sumatra. The study was approved by the medical ethics committee of Universitas Sumatera Utara. This study was numerical correlation analysis with cross sectional approach. The subject is 40 male schizophrenia. Cognitive function was assessed by MoCA-Ina. BDNF serum levels were analyzed using the quantitative sandwich enzyme immunoassay. Analysis of the data using Pearson correlation to see the correlation between MoCA-Ina Scoreand BDNF serum levels in schizophrenic patients. Mean of MoCA-Ina score was 21.03±5.21. It suggests that there was deficits of cognitive function in patients with schizophrenic disorder. Mean of serum levels of BDNF was 26629±6762. Pearson correlation coefficient between two variables was 0.434(p=0.005). Pearson correlation of MoCA-Ina Score and serum levels of BDNF showed a positive correlation with the strength of moderate correlation (r = 0.4 - <0.6).

Key Words: Cognitive, BDNF, Schizophrenia