Introduction: Patients with chronic kidney disease, have a higher risk for psychological distress such as anxiety, depression and cognitive decline. Combination Hemodialysis(HD) /hemoperfusion(HP) regularly able to eliminate uremic toxins with mild-to-large molecular weight better. HD/HPis able to remove metabolites, toxins and pathogenic factors and regulate the water, electrolyte and acid-base balance so as to improve the quality of patient's sleep and appetite also reduce itching of the skin, which in turn improve the quality and life expectancy, with lower scores and the degree of depression patients.

Methods: A pre-experimental research design with one group pretest-post test design conducted from July 2015 to September 2015 to 17 regular hemodialysis patients. Assessment using questionnaires BDI depression scores.

Results: T test results showed that the average BDI score before the combination of HD/HP 18.59±9 to 8.18±2.83 after the combination (p <0.001).

Conclusion: Combination HD/HP can lower depression scores in patients with regular HD.

 

Keywords:Hemodialysis, haemoperfusion, depression, BDI