Introduction.

Anthrax is a disease that affects animals and can be transmitted to humans. Direct contact is a risk factor for transmission of anthrax spores. Cutaneous anthrax is a clinical manifestation that mostly appears on anthrax exposure. Immune response of the body during an infection is the presence of antibodies as an effort to defend the body. These antibodies will survive for some time in the blood serum of people suffering from anthrax. The purpose of this study was to find out how the initial response to the formation of antibodies and how these antibodies survive after 1 year.

Material and methods.

This study is cohort to people exposed to anthrax to assess the clinical manifestations and antibody serum anthrax.

Results.

The study found 130 people exposed to anthrax. Forty-two exposed between 21 to 40 years old and mostly female. The highest level of education is 73.8% of primary school graduates. The most risk factor was direct contact and consumed infected animal meat, which was 34.6%. The serum IgG antibody result showed 50.5% negative, 14.6% borderline and 32.3% positive. Clinical manifestations of the skin were 12.3%, ie eschar  and all respondents showed positive Ig G. While 87.7% did not show any anthrax symptoms. Ig G serum  examination after 1 year of exposure to anthrax obtained 3.8% still detected antibodies in the body and 88.5% was negative. The relationship between Ig G titers with clinical manifestations of anthrax at one year post-outbreak is highly significant  p = 0.028.

Conclusion. There was a significant association between the clinical manifestation with antibody serum anthrax. But also found a positive Ig G without the appearance of clinical signs in the skin. Anthrax Protective Antigen ( PA ) ELISA Ig G still detected after one year post outbreaks of anthrax.

Keywords : Anthrax Protective Antigen, Eschar, Clinical manifestation