Last modified: 2017-10-27
Abstract
AbstraCT
Aim: To determine the difference of p53 expression based on radiation therapy response in cervical cancer.
Methods: this is an analytic study with case control design. This study was performed in Obstetric and Gynecology Department and Pathology Department of Adam Malik General Hospital Medan from January to February 2017. 15 paraffin blocks of cervical cancer patient with incomplete response were obtained as study samples, and 15 paraffin blocks of cervical cancer patient with complete response were obtained as control samples, The samples were collected by consecutive sampling and an immunohistochemical assessment of p53 expression was done to assess apoptosis count and radiation response. Data was analyzed using Kruskal-Wallis with confidence interval 83,5% and p<0,05 was statistically significant..
Result: from 30 paraffin blocks, 15 were from complete response group and 15 were from incomplete response group. Increase in p53 expression were found in samples with abundant apoptosis (≥ 5 apoptosis cells/5 HPF), p = 0.033, and in incomplete response group, p = 0.046.
Conclusion: p53 expression before radiation therapy can be used as an early marker for radiation therapy response in cervical cancer.
Keyword: p53 expression, advance stage cervical cancer, therapy response