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Abstract: Obesity has become an epidemic in both developed and developing countries. Central obesity is considered as a risk factor that is closely related to several chronic diseases. Central obesity is associated with elevated triglyceride levels and associated with RBP4 which can lead to insulin resistance. Increased level of RBP4 can cause lipid metabolism disorders and can become a marker for insulin resistance and metabolic syndrome.This study aims to find the correlation of RBP4 with triglycerides and Apo B100 in central obesity. This was a cross-sectional study on 46 subjects with central obesity, aged 20-50 years old. Blood samples were taken in cubital vein and examined for RBP4 and triglyceride levels. Data analysis was performed using Spearman correlation test. The results showed that gender frequency distribution showed little difference between men and women i.e. men 43.5% and women 56.5%. RBP4 level was positively correlated with triglyceride (r = 0.48) and statistically significant (p = 0.001). RBP4 level was positively correlated with triglyceride, indicating the role of RBP4 on high triglyceride level in central obesity.